Diabetische Folgeschäden: Eine Erkrankung der DNA? – Paul-Langerhans-Medaille 2022 – eine Kurzübersicht über den Preisträger Peter Nawroth

Peter P. Nawroth; Varun Kumar; Stefan Kopf

doi:10.1055/a-1902-4778

Diabetologie und Stoffwechsel, Table of Contents

Diabetologie und Stoffwechsel 2022; 17(05): 349-352
DOI: 10.1055/a-1902-4778

DDG-Preisträger

Diabetische Folgeschäden: Eine Erkrankung der DNA? – Paul-Langerhans-Medaille 2022 – eine Kurzübersicht über den Preisträger Peter Nawroth

Peter P. Nawroth

,

Varun Kumar

,

Stefan Kopf

Abstract

Full Text

References

Literatur
1 Wagner R, Heni M, Tabák AG. et al. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med 2021; 27 (01) 49-57
2 Zaharia OP, Strassburger K, Strom A. et al. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 2019; 7 (09) 684-694
3 Groener JB, Oikonomou D, Cheko R. et al. Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links. Exp Clin Endocrinol Diabetes 2019; 127 (08) 497-504
4 Schlotterer A, Kukudov G, Bozorgmehr F. et al. C. elegans as model for the study of high glucose- mediated life span reduction. Diabetes 2009; 58 (11) 2450-2456
5 Moraru A, Wiederstein J, Pfaff D. et al. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell Metab 2018; 27 (04) 926-934.e8
6 Bock F, Shahzad K, Wang H. et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci USA 2013; 110 (02) 648-653
7 Isermann B, Vinnikov IA, Madhusudhan T. et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007; 13 (11) 1349-1358
8 Rodier F, Coppé J-P, Patil CK. et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11 (08) 973-979
9 Schafer MJ, White TA, Iijima K. et al. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun 2017; 8: 14532
10 Bhatt S, Gupta MK, Khamaisi M. et al. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab 2015; 22 (02) 239-252
11 Kumar V, Fleming T, Terjung S. et al. Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic Acids Res 2017; 45 (18) 10595-10613
12 Kumar V, Agrawal R, Pandey A. et al. Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J 2020; 39 (11) e103477
13 Kopf S, Kumar V, Kender Z. et al. Diabetic Pneumopathy-A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations. Front Endocrinol (Lausanne) 2021; 12: 765201
14 Kumar V, Nawroth PP. Is the association between diabetes mellitus and pulmonary fibrosis real?. Nat Rev Endocrinol 2021; 17: 703-704